![]() ![]() Coma or brain death: Severe brain damage may cause a change in the size and reactivity of the pupils.Surgery: Eye surgery may result in alterations in pupil size, which can be permanent.Seizure: Sometimes seizures (a disruption of electrical activity in the brain) can cause changes in the pupils, which may be equal or unequal.Migraine: While it is not common, migraines can cause anisocoria.Vision loss: Significant vision defects can affect pupil size and reactivity. The defect, known as coloboma, involves the partial absence of ocular tissue in the iris, often affecting both eyes, leading to the elongated blackened area of.Increased intracranial pressure: This can result from a brain tumor, meningitis (inflammation of the fluid around the brain), or a stroke.Trauma: An injury affecting the eye or the brain may cause the pupils to be unequal.The pupil constricts or dilates (enlarges) according to the amount of light that enters the eyes, with both pupils normally dilating in dim light and constricting in bright light. Inflammatory conditions, such as MS and sarcoidosis, also can do this. In cats, the pupil is an elliptically-shaped opening in the middle of the iris that allows light to pass through the eye to the retina. Inflammation: An infection affecting the eye or the cranial nerves can cause anisocoria.Cranial nerve damage: This can occur due to a stroke (a blockage of blood flow or bleeding in the brain), brain aneurysm (defect in a blood vessel), or a brain tumor. ![]() Multiple sclerosis (MS): MS is a chronic neurological disorder that causes symptoms affecting vision, movement, sensation, and more. ![]()
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